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What (who) is extramedullary myeloma - definition
![protein electropherogram]] showing a paraprotein (peak in the gamma zone) in a person with multiple myeloma](https://commons.wikimedia.org/wiki/Special:FilePath/Monoclonal gammopathy Multiple Myeloma.png?width=200 "protein electropherogram]] showing a paraprotein (peak in the gamma zone) in a person with multiple myeloma")
![Plasmablast, [[Wright stain]], in a case of multiple myeloma of plasmablastic type.](https://commons.wikimedia.org/wiki/Special:FilePath/Plasmablast, Wright stain.png?width=200 "Plasmablast, [[Wright stain]], in a case of multiple myeloma of plasmablastic type.")
![Bone marrow aspirate showing the histologic correlate of multiple myeloma under the microscope, [[H&E stain]]](https://commons.wikimedia.org/wiki/Special:FilePath/Multiple myeloma (2) HE stain.jpg?width=200 "Bone marrow aspirate showing the histologic correlate of multiple myeloma under the microscope, [[H&E stain]]")
![[[Micrograph]] showing myeloma [[cast nephropathy]] in a [[kidney biopsy]]: Hyaline casts are PAS positive (dark pink/red – right of image). Myelomatous casts are PAS negative (pale pink – left of image), [[PAS stain]].](https://commons.wikimedia.org/wiki/Special:FilePath/Cast nephropathy - 2 cropped - very high mag.jpg?width=200 "[[Micrograph]] showing myeloma [[cast nephropathy]] in a [[kidney biopsy]]: Hyaline casts are PAS positive (dark pink/red – right of image). Myelomatous casts are PAS negative (pale pink – left of image), [[PAS stain]].")
![[[Micrograph]] of a [[plasmacytoma]], [[H&E stain]]](https://commons.wikimedia.org/wiki/Special:FilePath/Plasmacytoma_ultramini1.jpg?width=200 "[[Micrograph]] of a [[plasmacytoma]], [[H&E stain]]")
![petrous]] temporal bones involving the mastoid segment of the [[facial nerve]] canal. Red arrows: lesion; green arrow: normal contralateral facial nerve canal. The lesions are consistent with a myeloma deposit.](https://commons.wikimedia.org/wiki/Special:FilePath/Multiple myeloma skull CT arrows.PNG?width=200 "petrous]] temporal bones involving the mastoid segment of the [[facial nerve]] canal. Red arrows: lesion; green arrow: normal contralateral facial nerve canal. The lesions are consistent with a myeloma deposit.")
![CT scan of the lower vertebral column in a man with multiple myeloma, showing multiple osteoblastic lesions: These are more [[radiodense]] (brighter in this image) than the surrounding [[cancellous bone]], in contrast to osteolytic lesions, which are less radiodense.](https://commons.wikimedia.org/wiki/Special:FilePath/CT of osteoblastic lesions of multiple myeloma.jpg?width=200 "CT scan of the lower vertebral column in a man with multiple myeloma, showing multiple osteoblastic lesions: These are more [[radiodense]] (brighter in this image) than the surrounding [[cancellous bone]], in contrast to osteolytic lesions, which are less radiodense.")
![[[Femur]] with multiple myeloma lesions](https://commons.wikimedia.org/wiki/Special:FilePath/Left femur with myeloma.jpg?width=200 "[[Femur]] with multiple myeloma lesions")
![[[Humerus]] with multiple myeloma lesions](https://commons.wikimedia.org/wiki/Special:FilePath/Left humerus with myeloma.jpg?width=200 "[[Humerus]] with multiple myeloma lesions")
Wikipedia
Extramedullary hematopoiesis (EMH or sometimes EH) refers to hematopoiesis occurring outside of the medulla of the bone (bone marrow). It can be physiologic or pathologic.
Physiologic EMH occurs during embryonic and fetal development; during this time the main site of fetal hematopoiesis are liver and the spleen.
Pathologic EMH can occur during adulthood when physiologic hematopoiesis can't work properly in the bone marrow and the hematopoietic stem cells (HSC) have to migrate to other tissues in order to continue with the formation of blood cellular components. Pathologic EMH can be caused by myelofibrosis, thalassemias or disorders caused in the hematopoietic system.
